FIDELITY OF HUMAN OVARIAN CANCER PATIENT-DERIVED XENOGRAFTS IN A PARTIALLY HUMANIZED MOUSE MODEL FOR PRECLINICAL TESTING OF IMMUNOTHERAPIES

Fidelity of human ovarian cancer patient-derived xenografts in a partially humanized mouse model for preclinical testing of immunotherapies

Background Immune checkpoint blockers (ICBs) have been approved by the Food and Drug Administration to be used alone in front-line therapies or in combination with other regimens for certain advanced cancers.Since ICB only works in a SERENITY FORMULA subset of patients and has limited efficacy in treating ovarian cancer (OVC), developing preclinica

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Urban and Rural Landslide Hazard and Exposure Mapping Using Landsat and Corona Satellite Imagery for Tehran and the Alborz Mountains, Iran

Tehran, Karaj, Quazvin and nearby rural areas in the Alborz Mountains, Iran are Womens Dresses prone to earthquake and landslide hazards.Risks for settlement areas, transport infrastructure and pastoralist areas exist due to a combination of natural as well as man-made factors.This study analyses data derived from satellite and airborne sensors, sp

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Cross-Selectivity Enhancement of Poly(vinylidene fluoride-hexafluoropropylene)-Based Sensor Arrays for Detecting Acetone and Ethanol

Two methods for cross-selectivity enhancement of porous poly(vinylidene fluoride-hexafluoropropylene) (PVDF-HFP)/carbon black (CB) composite-based resistive sensors are provided.The sensors are tested with acetone and ethanol in the presence of humid air.Cross-selectivity is enhanced using two different methods to modify the basic response of the P

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Assessing sterility techniques in bronchodilator responsiveness testing by practicing allergists in North America

Background: The American Thoracic Society has published general guidelines for sterility when testing for bronchodilator responsiveness.However, the extent to which practicing allergists implement sterility measures is currently unknown.Objective: This study Dining Server aims to understand the adherence to the American Thoracic Society guidelines

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MeGLYI-13, a Glyoxalase I Gene in Cassava, Enhances the Tolerance of Yeast and Arabidopsis to Zinc and Copper Stresses

Although zinc and copper are the two essential nutrients necessary for plant growth, their excessive accumulation in soil not only causes environmental pollution but also seriously threatens human health and inhibits plant growth.The breeding of plants with novel zinc or copper toxicity tolerance capacities represents one strategy to address this p

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